Lavjay Butani
Chief and Professor
Pediatric Nephrology Department UC Davis Medical Center,
USA
Biography
Grande Joseph has worked as a renal pathologist at the Mayo Clinic for more than 20 years. His PhD work in pathology from the University of Chicago\'s Medical Scientist Training Program focused on the effects of hyperlipidemia and mechanical force on collagen production by aortic smooth muscle cells. After receiving post-doctoral training in pathology at the University of Michigan in 1991, he established an NIH-funded experimental renal research program at Mayo. Dr. Grande\'s research interests have focused on signaling mechanisms leading to chronic renal disease, with emphasis on inflammation, TGF-beta signaling, and a role of phosphodiesterase inhibitors in abrogating this process. He has collaborated with clinical nephrologists in basic, translational, and clinical studies related to a potential role of fish oil in preventing chronic renal disease, IgA nephropathy in particular. He has served as the study pathologist for DeKAF, an NIH-funded study to define histopathologic features of chronic renal allograft dysfunction. For this project, a number of quantitative histopathologic approaches to assess chronic renal disease, inflammation, and innate immune system activation were developed. More recently, his work has focused on critical signaling pathways responsible for chronic renal injury in renovascular hypertension.
Research Interest
Renal pathology, Understanding of basic mechanisms of fibrogenesis